Extremely Dangerous - Netflix

Neil Byrne is an ex-National Criminal Intelligence Service undercover agent convicted of the brutal murder of his wife and child who goes on the run to try and clear his name. He sets out to follow up a strange clue sent to him in prison. The boss of a local crime syndicate, a former associate, hears of his escape and sends out the word to bring him in. On the run from the police and disowned by his NCIS colleagues, he is faced with the fact that he may be guilty.

Extremely Dangerous - Netflix

Type: Scripted

Languages: English

Status: Ended

Runtime: 50 minutes

Premier: 1999-11-11

Extremely Dangerous - Congenital insensitivity to pain - Netflix

Congenital insensitivity to pain (CIP), also known as congenital analgesia, is one or more rare conditions in which a person cannot feel (and has never felt) physical pain. The conditions described here are separate from the HSAN group of disorders, which have more specific signs and cause. Because feeling physical pain is vital for survival, CIP is an extremely dangerous condition. It is common for people with the condition to die in childhood due to injuries or illnesses going unnoticed. Burn injuries are among the more common injuries.

Extremely Dangerous - Causes - Netflix

It may be that the condition is caused by increased production of endorphins in the brain. In this case, naloxone may be a treatment, but it does not always work. In all cases, this disorder can be in the voltage-gated sodium channel SCN9A (Nav1.7). Patients with such mutations are congenitally insensitive to pain and lack other neuropathies. There are three mutations in SCN9A: W897X, located in the P-loop of domain 2; I767X, located in the S2 segment of domain 2; and S459X, located in the linker region between domains 1 and 2. This results in a truncated non-functional protein. Nav1.7 channels are expressed at high levels in nociceptive neurons of the dorsal root ganglia. As these channels are likely involved in the formation and propagation of action potentials in such neurons, it is expected that a loss of function mutation in SCN9A leads to abolished nociceptive pain propagation. PRDM12 gene is normally switched on during the development of pain-sensing nerve cells. People with homozygous mutations of the PRDM12 gene experience congenital insensitivity to pain (CIP). Developmental disabilities such as autism can include varying degrees of pain insensitivity as a sign. However, since these disorders are characterized by dysfunction of the sensory system in general, this specific condition is not in itself an indicator of any of these conditions.

Extremely Dangerous - References - Netflix